Colossal Biosciences has claimed it "successfully restored" the extinct dire wolf after a "10,000+ year absence," but scientists clarify these are actually genetically modified grey wolves. The U.S. company announced three pups -- males Remus and Romulus born in October, and female Khaleesi born in January -- as dire wolves, but made only 20 genetic edits to grey wolves.

Beth Shapiro of Colossal told New Scientist that just 15 modifications were based on dire wolf DNA, primarily targeting size, musculature and ear shape. Five other changes involve mutations known to produce light coats in grey wolves. A 2021 DNA study revealed dire wolves and grey wolves last shared a common ancestor about 6 million years ago, with jackals and African wild dogs more closely related to grey wolves.

The internet's physical mass remains contested among scientists, with estimates ranging from a strawberry to something almost unimaginably small. In 2006, Harvard physicist Russell Seitz calculated the internet weighed roughly 50 grams based on server energy, a figure that would now equate to potato-weight given internet growth.

Christopher White, president of NEC Laboratories America, has dismissed this calculation as "just wrong." White suggests a more accurate method that accounts for the energy needed to encode all internet data in one place, yielding approximately 53 quadrillionths of a gram at room temperature. Alternatively, if the internet's projected 175 zettabytes of data were stored in DNA -- a storage medium scientists are actively exploring -- it would weigh 960,947 grams, equivalent to 10.6 American males. Though scientists debate measurement methods, White asserts the web's true complexity makes it "essentially unknowable."

Scientists "demonstrated a promising step toward using a person's own immune cells to fight gastrointestinal cancers" at America's National Institutes of Health (or NIH), reports the Washington Post.

But the results were published in Nature Medicine on Tuesday — "the same day the agency was hit with devastating layoffs..." The treatment approach is still early in its development; the personalized immunotherapy regimen shrank tumors in only about a quarter of the patients with colon, rectal and other GI cancers enrolled in a clinical trial. But a researcher who was not involved in the study called the results "remarkable" because they highlight a path to a frustratingly elusive goal in medicine — harnessing a person's own immune defenses to target common solid tumor cancers. Until now, cell-based immunotherapy has worked mainly on blood cancers, such as leukemia, but not the solid cancers that seed tumors in the breast, brain, lungs, pancreas and GI tract...

But the progress arrives at a sad time for science — and for patients, said the leader of the work, NIH immunotherapy pioneer Steven Rosenberg. Two patients' treatments using the experimental therapy had to be delayed because NIH's capacity to make personalized cell therapies has been slowed by the firing of highly skilled staff and by purchasing slowdowns. Those occurred even before major layoffs took place Tuesday... The Department of Health and Human Services (HHS) responded to an email asking about clinical trial delays with a statement: "NIH and HHS are complying with President Trump's executive order."
It's "a very exciting study," said Patrick Hwu, president of the Moffitt Cancer Center in Tampa. Finding ways to tailor this cell-based immunotherapy approach to common solid tumors that cause the vast majority of cancer deaths has remained a major scientific challenge... Rosenberg and colleagues first tried to create tumor infiltrating lymphocytes [or "TILs"] using the method that worked in melanoma for 18 patients with GI cancers that had spread. It failed completely. In a second iteration, his team sequenced the mutations present in each patient's tumor and used that information to sift out and expand the TILs that could home in on that patient's specific tumor cells. The results were far from a triumph, but provided a clue — this time, three of 39 patients' tumors shrank. In the last stage of the trial, the scientists added a drug called pembrolizumab that takes the brakes off immune cells. This time, eight of the 34 patients responded.

"Right now, only a few labs in the country can do what they just did," Hwu said.
While Rosenberg is already working "to refine and improve upon the results," he told the Post that two scientists involved in the specialized process of preparing the cells to treat patients were fired in the probationary purge. "We've had to slow down our work and delay the treatment of some patients...."

And there's also dramatically fewer people now who can purchase research materials, which the Post says it "making it slower and more difficult to obtain supplies."

Nuclear fusion — which releases four times the energy of fission — could theoretically happen sooner in space than on earth, reports CNN.

"And it could help spacecraft achieve speeds of up to 500,000 miles (805,000 kilometers) per hour — more than the fastest object ever built..." With funding from the UK Space Agency, British startup Pulsar Fusion has unveiled Sunbird, a space rocket concept designed to meet spacecraft in orbit, attach to them, and carry them to their destination at breakneck speed using nuclear fusion... For now, Sunbird is in the very early stages of construction and it has exceptional engineering challenges to overcome, but Pulsar says it hopes to achieve fusion in orbit for the first time in 2027. [Pulsar's founder/CEO says the first functional Sunbird would be ready four to five years later.]

If the rocket ever becomes operational, it could one day cut the journey time of a potential mission to Mars in half.
CNN says the proposed Sunbird process would use helium-3 — which may be abundant on the Moon — to generate protons which "can be used as a 'nuclear exhaust' to provide propulsion". (And without generating any dangerous radioactive material.) "It's very unnatural to do fusion on Earth," says Richard Dinan, founder and CEO of Pulsar. "Fusion doesn't want to work in an atmosphere. Space is a far more logical, sensible place to do fusion, because that's where it wants to happen anyway...."

Sunbirds would operate similarly to city bikes at docking stations, according to Dinan: "We launch them into space, and we would have a charging station where they could sit and then meet your ship," he says. "You turn off your inefficient combustion engines, and use nuclear fusion for the greater part of your journey. Ideally, you'd have a station somewhere near Mars, and you'd have a station on low Earth orbit, and the (Sunbirds) would just go back and forth...." Initially, the Sunbirds will be offered for shuttling satellites in orbit, but their true potential would come into play with interplanetary missions. The company illustrates a few examples of the missions that Sunbird could unlock, such as delivering up to 2,000 kilograms (4,400 pounds) of cargo to Mars in under six months, deploying probes to Jupiter or Saturn in two to four years (NASA's Europa Clipper, launched in 2024 towards one of Jupiter's moons, will arrive after 5.5 years), and an asteroid mining mission that would complete a round trip to a near-Earth asteroid in one to two years instead of three.

Other companies are working on nuclear fusion engines for space propulsion, including Pasadena-based Helicity Space, which received investment from aerospace giant Lockheed Martin in 2024. San Diego-based General Atomics and NASA are working on another type of nuclear reactor — based on fission rather than fusion — which they plan to test in space in 2027.

"I started working on Voyager in 1977," the Voyager mission's project scientist told Gizmodo Saturday in a new interview. "It was my first job out of college."

35 years later, a Voyager probe became the first spacecraft to cross into interstellar space in 2012, with Voyager 2 following in 2018. But while each Voyager spacecraft carries 10 scientific instruments, all but three have now been turned off to conserve power, Gizmodo writes. "The two spacecraft now have enough power to operate for another year or so before engineers are forced to turn off two more instruments..." Voyager Mission Project Scientist Linda Spilker: The number of people that are working on and flying Voyager is a whole lot smaller than it was in the planetary days... The challenge was, can we reach the heliopause? We didn't know where it was, we had no idea how far away it was. We got to Neptune, and then we thought, "well, maybe it's just another 10 [astronomical units] or so, a little bit further, a little bit further." And so every time we got a little bit further, the modelers would go back, scratch their heads and say, "ah, it could be a little bit more, a little bit farther away," and so on and on that continued, until finally, Voyager 1 crossed the heliopause in 2012...

Gizmodo: Is it an emotional decision to turn off Voyager's instruments?

Spilker: I was talking to the cosmic ray instrument lead, and I said, "Wow, this must really be tough for you to see your instrument turned off." He helped build the instrument in the early 1970s. This instrument that's been sending you data, and that's been part of your life for over 50 years now. And he said, it was hard to think about turning it off for the whole team. It's kind of like losing a best friend, or someone that's been a part of your life for so many years, and then suddenly, it's silent. At the same time, there's this pride that you were part of that, and your instrument got so much great data — so it's a mix of emotions...

The spacecraft had a lot of redundancy on it, so that means two of every computer and two of all the key components. We've been able to turn off those backup units, but we're now at the point where, to really get a significant amount of power, all that's left are some of the science instruments to turn off. So, that's where we're at... How cold can the lines get before they freeze? How cold can some of these other components get before they stop working? So that's another challenge. Then there are individual tiny thrusters that align the spacecraft and keep that antenna pointed at the Earth so we can send the data back, and they're very slowly clogging up with little bits of silica, and so their puffs are getting weaker and weaker. That's another challenge that we're going through to balance.

But we're hopeful that we can get one, possibly two, spacecraft to the 50th anniversary in 2027. Voyager's golden anniversary, and perhaps even into the early 2030s with one, maybe two, science instruments.
"We're well past the warranty of four years..." Spilker says at one point. And "We're still working and thinking about an interstellar probe that would go much, much farther than Voyager.

"You're talking about a multi-generation mission."

The Starliner spacecraft lost four thrusters while approaching the International Space Station last summer. NASA astronaut, Butch Wilmore took manual control, remembers Ars Technica, "But as Starliner's thrusters failed, Wilmore lost the ability to move the spacecraft in the direction he wanted to go..." Starliner had flown to within a stone's throw of the space station, a safe harbor, if only they could reach it. But already, the failure of so many thrusters violated the mission's flight rules. In such an instance, they were supposed to turn around and come back to Earth. Approaching the station was deemed too risky for Wilmore and Williams, aboard Starliner, as well as for the astronauts on the $100 billion space station.

But what if it was not safe to come home, either?

"I don't know that we can come back to Earth at that point," Wilmore said in an interview. "I don't know if we can. And matter of fact, I'm thinking we probably can't."
After a half-hour exclusive interview, Ars Technica's senior space editor Eric Berger says he'd heard "a hell of a story." After Starliner lost four of its 28 reaction control system thrusters, Van Cise and this team in Houston decided the best chance for success was resetting the failed thrusters. This is, effectively, a fancy way of turning off your computer and rebooting it to try to fix the problem. But it meant Wilmore had to go hands-off from Starliner's controls. Imagine that. You're drifting away from the space station, trying to maintain your position. The station is your only real lifeline because if you lose the ability to dock, the chance of coming back in one piece is quite low. And now you're being told to take your hands off the controls...

Two of the four thrusters came back online.

Wilmore: "...But then we lose a fifth jet. What if we'd have lost that fifth jet while those other four were still down? I have no idea what would've happened. I attribute to the providence of the Lord getting those two jets back before that fifth one failed...

Berger: Mission Control decided that it wanted to try to recover the failed thrusters again. After Wilmore took his hands off the controls, this process recovered all but one of them. At that point, the vehicle could be flown autonomously, as it was intended to be.
"Wilmore added that he felt pretty confident, in the aftermath of docking to the space station, that Starliner probably would not be their ride home," according to the article. And Williams says it was the right decision. Publicly, NASA and Boeing expressed confidence in Starliner's safe return with crew. But Williams and Wilmore, who had just made that harrowing ride, felt differently.

This week NASA "issued a solicitation for the next two private astronaut missions to the International Space Station," reports Space News. Scheduled after May of 2026 and then mid-2027, "These will be the fifth and sixth such missions to the ISS, part of a broader low Earth orbit commercialization effort by NASA with the ultimate goal of replacing the International Space Station with one or more commercial stations."

NASA's Space Station program manager calls the missions "a key part" of helping industry partners "gain the experience needed to train and manage crews, conduct research, and develop future destinations." In short, they see the missions "providing companies with hands-on opportunities to refine their capabilities and build partnerships that will shape the future of low Earth orbit." [NASA's call for proposals] offers an opportunity to have future missions commanded by someone other than a former NASA astronaut. While companies must propose a commander who meets current requirements, it can also propose an alternate commander who is a former astronaut from the Canadian Space Agency, European Space Agency or Japan Aerospace Exploration Agency with similar ISS experience requirements... ["Broadening of this requirement is not guaranteed," NASA warns.]

That could allow some former astronauts already working with commercial spaceflight companies an opportunity to command private astronaut missions. Axiom Space, for example, announced in July 2024 that former ESA astronaut Tim Peake had joined its astronaut team. That came after Axiom and the U.K. Space Agency signed a memorandum of understanding in October 2023 to study the feasibility of a private astronaut mission crewed exclusively by U.K. astronauts.
So far Axiom Space has been awarded all four private astronaut missions, according to the article, "flying one mission each in 2022, 2023 and 2024. Its next mission, Ax-4, is scheduled for no earlier than May."

But "While Axiom has little or no competition for previous PAM awards, it will likely face stiffer competition this time. Vast, a company also planning to develop commercial space stations, has previously stated its intent to submit proposals..."

A new study shows bonobos can combine vocal calls in ways that mirror human language, producing phrases with meanings beyond the sum of individual sounds. "Human language is not as unique as we thought," said Dr Melissa Berthet, the first author of the research from the University of Zurich. Another author, Dr Simon Townsend, said: "The cognitive building blocks that facilitate this capacity is at least 7m years old. And I think that is a really cool finding." The Guardian reports: Writing in the journal Science, Berthet and colleagues said that in the human language, words were often combined to produce phrases that either had a meaning that was simply the sum of its parts, or a meaning that was related to, but differed from, those of the constituent words. "'Blond dancer' -- it's a person that is both blond and a dancer, you just have to add the meanings. But a 'bad dancer' is not a person that is bad and a dancer," said Berthet. "So bad is really modifying the meaning of dancer here." It was previously thought animals such as birds and chimpanzees were only able to produce the former type of combination, but scientists have found bonobos can create both.

The team recorded 700 vocalizations from 30 adult bonobos in the Democratic Republic of the Congo, checking the context of each against a list of 300 possible situations or descriptions. The results reveal bonobos have seven different types of call, used in 19 different combinations. Of these, 15 require further analysis, but four appear to follow the rules of human sentences. Yelps -- thought to mean "'et's do that" -- followed by grunts -- thought to mean "look at what I am doing," were combined to make "yelp-grunt," which appeared to mean "let's do what I'm doing." The combination, the team said, reflected the sum of its parts and was used by bonobos to encourage others to build their night nests.

The other three combinations had a meaning apparently related to, but different from, their constituent calls. For example, the team found a peep -- which roughly means "I would like to ..." -- followed by a whistle -- appeared to mean "let's stay together" -- could be combined to create "peep-whistle." This combination was used to smooth over tense social situations, such as during mating or displays of prowess. The team speculated its meaning was akin to "let's find peace." The team said the findings in bonobos, together with the previous work in chimps, had implications for the evolution of language in humans, given all three species showed the ability to combine words or vocalizations to create phrases.

SpaceX's Fram2 mission returned safely after becoming the first crewed spaceflight to orbit directly over Earth's poles. From a report: Led by cryptocurrency billionaire Chun Wang, who is the financier of this mission, the Fram2 crew has been free-flying through orbit since Monday. The group splashed down at 9:19 a.m. PT, or 12:19 p.m. ET, off the coast of California -- the first West Coast landing in SpaceX's five-year history of human spaceflight missions. The company livestreamed the splashdown and recovery of the capsule on its website.

During the journey, the Fram2 crew members were slated to carry out various research projects, including capturing images of auroras from space and documenting their experiences with motion sickness. [...] This trip is privately funded, and such missions allow for SpaceX's customers to spend their time in space as they see fit. For Fram2, the crew traveled to orbit prepared to carry out 22 research and science experiments, some of which were designed and overseen by SpaceX. Most of the research involves evaluating crew health.

Indonesian President Prabowo Subianto's ambitious plan to create 1 million hectares of new rice farms in eastern Merauke Regency faces strong criticism from scientists who have warned it will fail due to unsuitable soils and climate. Military "food brigades" are currently guarding bulldozers clearing swampy forests in Indonesian New Guinea for the project, which aims to boost food self-sufficiency for the nation's 281 million people.

Soil scientists warn that Merauke's conditions could lead to acidic soils unable to support economically viable rice farming, potentially resulting in abandoned fields vulnerable to wildfires. "Farmers will get no profit at all," said Dwi Andreas, a soil scientist at Bogor Agricultural University who tested 12 rice varieties in similar soils with poor results.

The initiative mirrors past failed megaprojects, including a 1990s attempt to convert 1 million hectares of Borneo peatlands to rice paddies and a 2020 onion and potato farming expansion in North Sumatra that saw 90% of fields abandoned. A previous 2010 attempt to expand rice farming in Merauke also failed, destroying forests that Indigenous Papuans relied on and increasing childhood malnutrition, according to anthropologist Laksmi Adriani.

The European Space Agency's short film Space Debris: Is it a Crisis? highlights the growing danger of orbital clutter, warning that "70% of the 20,000 satellites ever launched remain in space today, orbiting alongside hundreds of millions of fragments left behind by collisions, explosions and intentional destruction." Inkl reports: The approximately eight-minute-long film "Space Debris: Is it a Crisis?" attempts to answer its conjecture with supportive statistics and orbital projections. [...] The film also mentions that the kind of Earth orbit matters when discussing whether we're in a space junk "crisis" -- though unfortunately, orbits at risk appear to be those with satellites that help with communication and navigation, as well as our fight against another primarily human-driven crisis: global warming. Still, the film emphasizes that solutions ought to be thought of carefully: "True sustainability is complex, and rushed solutions risk creating the problem of burden-shifting." You can watch the film on ESA's website.

Longtime Slashdot reader backslashdot writes: Commentary, video, and a publication in this week's Nature Neuroscience herald a significant advance in brain-computer interface (BCI) technology, enabling speech by decoding electrical activity in the brain's sensorimotor cortex in real-time. Researchers from UC Berkeley and UCSF employed deep learning recurrent neural network transducer models to decode neural signals in 80-millisecond intervals, generating fluent, intelligible speech tailored to each participant's pre-injury voice. Unlike earlier methods that synthesized speech only after a full sentence was completed, this system can detect and vocalize words within just three seconds. It is accomplished via a 253-electrode array chip implant on the brain. Code and the dataset to replicate the main findings of this study are available in the Chang Lab's public GitHub repository.

The James Webb Space Telescope has revealed that a surprising majority of galaxies rotate clockwise, challenging the long-held belief in a directionally uniform universe; this anomaly could suggest either our universe originated inside a rotating black hole or that astronomers have been misinterpreting the universe's expansion due to observational biases. Smithsonian Magazine reports: The problem is that astronomers have long posited that galaxies should be evenly split between rotating in one direction or the other, astronomer Dan Weisz from the University of California, Berkeley, who was not involved with the study, wrote for Astronomy back in 2017. "This stems from the idea that we live in an 'isotropic' universe, which means that the universe looks roughly the same in every direction. By extension, galaxies shouldn't have a preferred direction of spin from our perspective," he added. According to Shamir, there are two strong potential explanations for this discrepancy. One explanation is that the universe came into existence while in rotation. This theory would support what's known as black hole cosmology: the hypothesis that our universe exists within a black hole that exists within another parent universe. In other words, black holes create universes within themselves, meaning that the black holes in our own universe also lead to other baby universes.

"A preferred axis in our universe, inherited by the axis of rotation of its parent black hole, might have influenced the rotation dynamics of galaxies, creating the observed clockwise-counterclockwise asymmetry," Nikodem Poplawski, a theoretical physicist at the University of New Haven who was not involved in the study, tells Space.com's Robert Lea. "The discovery by the JWST that galaxies rotate in a preferred direction would support the theory of black holes creating new universes, and I would be extremely excited if these findings are confirmed."

Another possible explanation involves the Milky Way's rotation. Due to an effect called the Doppler shift, astronomers expect galaxies rotating opposite to the Milky Way's motion to appear brighter, which could explain their overrepresentation in telescopic surveys. "If that is indeed the case, we will need to re-calibrate our distance measurements for the deep universe," Shamir explains in the statement. "The re-calibration of distance measurements can also explain several other unsolved questions in cosmology such as the differences in the expansion rates of the universe and the large galaxies that according to the existing distance measurements are expected to be older than the universe itself." The findings have been published in the journal Monthly Notices of the Royal Astronomical Society.

An anonymous reader quotes a report from Ars Technica: The first flight of Isar Aerospace's Spectrum rocket didn't last long on Sunday. The booster's nine engines switched off as the rocket cartwheeled upside-down and fell a short distance from its Arctic launch pad in Norway, punctuating the abbreviated test flight with a spectacular fiery crash into the sea. If officials at Isar Aerospace were able to pick the outcome of their first test flight, it wouldn't be this. However, the result has precedent. The first launch of SpaceX's Falcon 1 rocket in 2006 ended in similar fashion. "Today, we know twice as much about our launch system as yesterday before launch," Daniel Metzler, Isar's co-founder and CEO, wrote on X early Monday. "Can't beat flight testing. Ploughing through lots of data now."

Isar Aerospace, based in Germany, is the first in a crop of new European rocket companies to attempt an orbital launch. If all went according to plan, Isar's Spectrum rocket would have arced to the north from Andoya Spaceport in Norway and reached a polar orbit. But officials knew there was only a low chance of reaching orbit on the first flight. For this reason, Isar did not fly any customer payloads on the Spectrum rocket, designed to deliver up to 2,200 pounds (1,000 kilograms) of payload mass to low-Earth orbit. [...] Isar declared the launch a success in its public statements, but was it? [...] Metzler, Isar's chief executive, was asked last year what he would consider a successful inaugural flight of Spectrum. "For me, the first flight will be a success if we don't blow up the launch site," he said at the Handelsblatt innovation conference. "That would probably be the thing that would set us back the most in terms of technology and time."

This tempering of expectations sounds remarkably similar to statements made by Elon Musk about SpaceX's first flight of the Starship rocket in 2023. By this measure, Isar officials can be content with Sunday's result. The company is modeling its test strategy on SpaceX's iterative development cycle, where engineers test early, make fixes, and fly again. This is in stark contrast to the way Europe has traditionally developed rockets. The alternative to Isar's approach could be to "spend 15 years researching, doing simulations, and then getting it right the first time," Metzler said. With the first launch of Spectrum, Isar has tested the rocket. Now, it's time to make fixes and fly again. That, Isar's leaders argue, will be the real measure of success. "We're super happy," Metzler said in a press call after Sunday's flight. "It's a time for people to be proud of, and for Europe, frankly, also to be proud of." You can watch a replay of the live launch webcast on YouTube.

An anonymous reader quotes a report from 404 Media: The creator of an open source genetic database is shutting it down and deleting all of its data because he has come to believe that its existence is dangerous with "a rise in far-right and other authoritarian governments" in the United States and elsewhere. "The largest use case for DTC genetic data was not biomedical research or research in big pharma," Bastian Greshake Tzovaras, the founder of OpenSNP, wrote in a blog post. "Instead, the transformative impact of the data came to fruition among law enforcement agencies, who have put the genealogical properties of genetic data to use."

OpenSNP has collected roughly 7,500 genomes over the last 14 years, primarily by allowing people to voluntarily submit their own genetic information they have downloaded from 23andMe. With the bankruptcy of 23andMe, increased interest in genetic data by law enforcement, and the return of Donald Trump and rise of authoritarian governments worldwide, Greshake Tzovaras told 404 Media he no longer believes it is ethical to run the database. "I've been thinking about it since 23andMe was on the verge of bankruptcy and been really considering it since the U.S. election. It definitely is really bad over there [in the United States]," Greshake Tzovaras told 404 Media. "I am quite relieved to have made the decision and come to a conclusion. It's been weighing on my mind for a long time."

Greshake Tzovaras said that he is proud of the OpenSNP project, but that, in a world where scientific data is being censored and deleted and where the Trump administration has focused on criminalizing immigrants and trans people, he now believes that the most responsible thing to do is to delete the data and shut down the project. "Most people in OpenSNP may not be at particular risk right now, but there are people from vulnerable populations in here as well," Greshake Tzovaras said. "Thinking about gender representation, minorities, sexual orientation -- 23andMe has been working on the whole 'gay gene' thing, it's conceivable that this would at some point in the future become an issue." "Across the globe there is a rise in far-right and other authoritarian governments. While they are cracking down on free and open societies, they are also dedicated to replacing scientific thought and reasoning with pseudoscience across disciplines," Greshake Tzovaras wrote. "The risk/benefit calculus of providing free & open access to individual genetic data in 2025 is very different compared to 14 years ago. And so, sunsetting openSNP -- along with deleting the data stored within it -- feels like it is the most responsible act of stewardship for these data today."

"The interesting thing to me is there are data preservation efforts in the U.S. because the government is deleting scientific data that they don't like. This is approaching that same problem from a different direction," he added. "We need to protect the people in this database. I am supportive of preserving scientific data and knowledge, but the data comes second -- the people come first. We prefer deleting the data."